
Common Questions
Find evidence-based information to answer your questions and support your decisions around vaccination in pregnancy.
Quick Facts
-
Pregnant people are at higher risk of serious illness.
Changes in your heart, lungs, and immune system during pregnancy make you more likely to get seriously ill from infections like the flu compared to someone who is not pregnant.
-
Young babies are at higher risk of serious illness.
Babies are especially vulnerable to serious illness from infections like RSV, pertussis (whooping cough), and flu during their first few months of life.
-
Vaccination during pregnancy helps protect you.
Getting vaccinated during pregnancy lowers your risk of serious illness and hospitalization from common infections like the flu and COVID-19.
-
Vaccination during pregnancy helps protect your baby.
When you get vaccinated during pregnancy, your body makes protective antibodies that pass to your baby through the placenta—helping protect them from serious illness in their first months of life.
-
The vaccines recommended in pregnancy are safe.
Real-world evidence from millions of pregnant people shows that these vaccines are safe and do not increase the risk of miscarriage, birth defects, or other complications.
-
Talk to your healthcare provider about timing.
Some vaccines are given at specific points in pregnancy, while others can be given anytime. Your healthcare provider can help you know what’s recommended and where to get it.
Which Vaccines Are Recommended in Pregnancy?
Understanding Vaccines
-
The immune system
Your immune system is your body’s natural defence system. It’s made up of organs, cells, and proteins that work together to protect you from harmful germs like viruses and bacteria.
When a new germ (virus or bacteria) enters your body, your immune system responds by making proteins called antibodies, which help find and destroy the germ.
The first time your body encounters a new germ, your immune system needs time to figure out how to respond and start making antibodies. During this time, you might get sick.
Once your immune system learns how to fight the germ, it usually remembers it. If the same germ enters your body again, your immune system can recognize it quickly and respond fast enough to destroy it before it has a chance to make you sick.
Where do vaccines come in?
Vaccines give your immune system a safe “practice run” by showing it a harmless version or piece of a germ. This teaches your body how to recognize and fight the germ without the risk of getting sick first.
Many vaccines, like flu and Tdap vaccines, use tiny, inactivated (dead) or weakened pieces of the germ called antigens. These antigens can’t make you sick, but they help your immune system learn what to look out for. Other vaccines, like mRNA COVID-19 vaccines, give your body the instructions to make the antigens on its own.
After you get a vaccine, your immune system treats the antigen as if it were the real germ. It responds by making protective antibodies to fight against it. It also creates memory cells that stay in your body and help your immune system quickly recognize and respond if you're exposed to the real germ in the future. This fast response helps destroy the germ before it has a chance to make you sick.
Some vaccines provide long-lasting protection, working for many years or even decades. Others protect you for a shorter time and may need additional “booster” shots to keep your immunity (protection) strong.
-
Vaccines teach your body how to recognize and fight off germs, but they do this in different ways depending on how they’re made.
Inactivated vaccines
Inactivated vaccines use a dead germ or pieces of the germ, called antigens. Because the germ is not alive, it can’t cause illness. You can think of these germs as being “switched off.”
These vaccines are safe to receive during pregnancy because they do not contain any live germs.
Common examples of inactivated vaccines include the flu vaccine and the Tdap vaccine, which protects against tetanus, diphtheria, and pertussis (whooping cough).
Live and live-attenuated vaccines
Live and live-attenuated vaccines use a weakened form of the germ that is still alive but has been changed so it can’t cause disease in healthy people. Common examples include the MMR vaccine (for measles, mumps, and rubella) and the chickenpox (varicella) vaccine.
These vaccines are not routinely recommended during pregnancy due to a small theoretical risk to the developing baby. This means that based on how the vaccines work, there is a possibility they could affect the baby—but this has not been seen in real-life studies.
In fact, research shows that babies born to people who received a live or live-attenuated vaccine during pregnancy—often before knowing they were pregnant—do not have higher rates of birth defects or infections related to the vaccine.1
Getting one of these vaccines while pregnant is not a reason to consider ending a pregnancy.
mRNA Vaccines
mRNA vaccines work differently than inactivated or live vaccines. Instead of giving your body a weakened or dead piece of a germ (called an antigen), mRNA vaccines provide instructions that help your body make the antigen on its own.
These vaccines are safe to receive during pregnancy because they do not contain any live germs. This means they cannot give you COVID-19 or harm you or your baby.
The Pfizer-BioNTech and Moderna COVID-19 vaccines are examples of mRNA vaccines.
The vaccines recommended during pregnancy—flu, Tdap, mRNA COVID-19, and RSVpreF—do not contain any live germs and are safe for both pregnant people and their babies.
-
In Canada, the following vaccines are recommended for all pregnant individuals:
Tdap vaccine (tetanus, diphtheria, and pertussis)
RSV (RSVpreF) vaccine – approved by Health Canada in 2023 to help prevent severe RSV infections in young babies
These vaccines are safe to receive during pregnancy because they do not contain live germs. This means they cannot give you the disease or harm you or your baby. Studies show that getting vaccinated during pregnancy is safe and helps protect your baby in the first few months of life, when they are most vulnerable to getting very sick from infections.
In some cases, other vaccines may be recommended during pregnancy—for example, if you're traveling or have certain health risks. Talk to your healthcare provider to find out which vaccines are right for you.
-
Vaccines teach your body to make protective antibodies that help fight off germs like viruses and bacteria. During pregnancy, these antibodies naturally pass through the placenta to your baby, giving them early protection against harmful germs until they’re old enough to get their own vaccines.

Getting vaccinated helps protect you and your baby from infections like the flu, COVID-19 and pertussis (whooping cough).
What’s in a Vaccine?
Every ingredient in a vaccine plays an important role, either in creating the vaccine or helping to keep it safe and effective.¹
Each ingredient in a vaccine serves a specific purpose. Some ingredients help your immune system respond better to the vaccine, while others make sure the vaccine stays safe and effective during storage and use.¹ For example, vaccines usually contain certain ingredients to prevent contamination and to keep the vaccine effective over time.
All vaccine ingredients are carefully studied and proven to be safe in the small amounts used.¹ Health Canada strictly regulates all vaccine ingredients and has strict rules to make sure they are safe for everyone who receives them.
-
Antigens are the part of a vaccine that teaches your immune system how to recognize and fight off harmful germs. They are usually made from a killed or weakened virus or bacteria, or a small piece of it.1 Some vaccines, like mRNA COVID-19 vaccines, don’t contain the antigen itself but give your body instructions to make the antigen on its own.
Antigens trigger your immune system to produce special proteins called antibodies. Antibodies recognize and attach to specific germs, helping your body find and destroy them. These antibodies stay in your body for some time and help protect you if you're exposed to the real germ in the future.
-
Adjuvants are substances added to some vaccines to help strengthen the body’s immune response to the vaccine (i.e., they help the vaccine work better).¹ Not all vaccines contain adjuvants. The most commonly used adjuvants are salts called aluminum hydroxide, aluminum sulphate and potassium aluminum sulphate. They are commonly referred to as ‘alum.’ Aluminum is one of the most common elements on earth. It's in the air we breathe, the water we drink, the food we eat, and many health products.¹ The amount of aluminum in vaccines is very small and doesn’t pose any health risks. In fact, the amount of aluminum contained in vaccines is smaller than the amount found naturally in other things children consume, such as breastmilk and formula.²
-
Preservatives are used in some vaccines to protect them from becoming contaminated with harmful germs, like bacteria or fungi. One of the most common preservatives used in some vaccines is 2-phenoxyethanol, which can also be found in many cosmetics, baby care products, and eye and ear drops.³
-
Stabilizers help prevent vaccine ingredients from breaking down (spoiling) while vaccines are being made, stored, and transported.¹ Common stabilizers include sugars, salts, or oils, which are also found in everyday food.
-
Residues are tiny amounts of substances that remain in the vaccine after the manufacturing process. Most of these substances are removed from the final vaccine product, but small amounts may remain. In such tiny amounts, these residues are harmless, and most are already present in our bodies. For example, tiny traces of formaldehyde can be detected in some vaccines. Formaldehyde is used to inactivate (kill) viruses and bacteria so they can be safely used as antigens in vaccines. Human bodies naturally produce larger amounts of formaldehyde than found in vaccines.¹
-
The diluent used in vaccines is usually sterile water or saline (salt water). Diluents have no effect on the body. They are included in vaccines to ensure that the smallest useful dose can be used. Vaccines are mostly made up of water or saline.
-
mRNA COVID-19 vaccines work differently than other vaccines recommended during pregnancy. Instead of using a killed (inactivated) part of the virus, they use messenger RNA (mRNA)—a set of instructions that teaches your body how to make a harmless piece of the virus.
Coronaviruses, including the one that causes COVID-19, have crown-shaped spikes on their surface called spike proteins.⁴ The mRNA in the vaccine tells your cells how to make a harmless copy of this spike protein.
Once your cells make the spike protein, your immune system sees it as an intruder. In response, it creates protective antibodies and memory cells. These will recognize and fight off the real virus if you're exposed in the future.
mRNA COVID-19 vaccines do not contain live virus and cannot give you COVID-19.
The other ingredients used in mRNA COVID-19 vaccines include sugars, salts, and lipids (fats). Many of these ingredients are commonly found in the everyday food we eat.⁵
Lipids (fats): Think of lipids as little protective bubbles. They surround the delicate mRNA to keep it safe. This means the mRNA doesn't break down too quickly once inside your body. Lipids also work together to help mRNA enter cells.⁵
Salt, sugar and acid stabilizers: These help keep the vaccine stable (in good condition) while it is produced, frozen, shipped, and stored.⁵
After the vaccine has finished teaching your immune system how to defend against the COVID-19 virus, your body will naturally break down and remove the vaccine ingredients, just like it does with other substances it no longer needs.⁵
-
You can find a table with a list of the ingredients used in vaccines approved in Canada in Part 1 of the Canadian Immunization Guide
You can find a list of ingredients included in each COVID-19 vaccine approved for use in Canada on the Government of Canada website
You can also find a list of vaccine ingredients in the vaccine's product monograph, which are available through Health Canada's Drug Product Database
Vaccine Safety
-
Vaccines are among the most strictly regulated medical products in Canada.⁶
All vaccines go through in-depth and rigorous testing processes and must pass through three phases of clinical trials to show that they are safe and effective before they are approved for use in Canada.⁶ Once vaccines are approved for use, they continue to be monitored for safety and effectiveness (how well they are working to protect individuals and the population). Any problems people might have after getting vaccinated are carefully tracked and looked into.⁷
Pre-Clinical Phase (Lab Testing): Before any testing in humans, vaccines are studied in laboratories. If lab studies show that the vaccine has good potential to protect against a disease, they are then studied in animals. This helps researchers see if the vaccine is safe and effective and to spot any possible risks. This phase also involves developmental and reproductive toxicity (DART) studies, where the vaccine is tested in animals before and during pregnancy. These studies are used to determine if the vaccine has any negative effects on the animals' ability to reproduce (have babies), the pregnancy itself, or on the health and development of the babies. DART studies give us important information on the potential risks and safety of vaccines during pregnancy.
Clinical Trials: If a vaccine is shown to be safe and effective in animals, it is then studied in humans. People taking part in these studies are volunteers who choose to participate in the research and are fully informed about the possible risks and benefits.⁶⁻⁷ There are three phases (stages) of clinical trials that study the safety and effectiveness of a vaccine in humans⁸:
Phase 1: A small group of healthy volunteers is given the vaccine to check its safety, figure out the right dose, and identify any major side effects.
Phase 2: The vaccine is given to a larger group (generally hundreds of people) to test how well it works, if it is safe in a larger number of people and learn more about the safest and most effective dose.
Phase 3: If the vaccine is effective and safe, it is then given to a much larger group (generally thousands of people) to confirm that it protects against the disease in large populations and to check for any uncommon or serious side effects.
Review by Health Experts: Health Canada, a government agency, carefully reviews all the information from these tests to decide if the vaccine is safe, of high quality, and effective.⁷
Approval: If the vaccine passes all of these tests and the review by Health Canada, it gets approval.⁷ Health Canada only approves a vaccine for use if it has been proven to be safe and effective and only if the benefits of the vaccine greatly outweigh any potential risks associated with it.⁷
Ongoing Safety Checks: Even after a vaccine is approved, its safety and effectiveness are continuously monitored. Any problems people might have after getting the vaccine are tracked and looked into.⁷
Reporting Problems: If someone has a problem after getting the vaccine, healthcare professionals or the public can report it to Health Canada. This is part of a program that helps identify if there are any safety issues that need further investigation.
This step-by-step process is in place to make sure that vaccines used in Canada meet the highest safety and effectiveness standards.
-
During the COVID-19 pandemic, Health Canada made it a priority to approve vaccines quickly to get them to people as soon as possible. They did this by:
Letting vaccine manufacturers submit their research data as soon as it was available, and
Allowing Health Canada experts to review it immediately.⁹
Importantly, this faster process did not mean that safety was overlooked. Vaccines were approved only after a complete and careful review of all the required safety data.⁹
Health Canada maintained its strict standards for vaccine review during this expedited process. This means each vaccine still had to be proven safe, effective, and of high quality before being approved by Health Canada.10
Vaccines were still required to go through in-depth clinical trials to confirm their safety and effectiveness.⁹ Health Canada only approved vaccines after receiving enough evidence that they were safe and effective.10-11
-
Once a vaccine is approved, its safety continues to be closely monitored. Sometimes, side effects are so rare that they aren't detected even when millions of people have received the vaccine.⁶ Because of this, monitoring for safety continues even after a vaccine is approved and widely used.
Once it is in use, there are several systems in place to monitor a vaccine’s safety. Adverse (bad) reactions or events after vaccination are reported in each province and territory and are also reported to the Government of Canada. An Adverse Event Following Immunization (also known as an AEFI) is an unwanted or unexpected change in health that happens after someone receives a vaccine.12 Adverse events are tracked and studied carefully, and every serious event is reviewed in detail.
-
Health Canada and the Public Health Agency of Canada (PHAC) work together to identify and review any vaccine safety concerns.13 Health Canada and PHAC regularly review AEFI (adverse events following immunization) reports submitted to their databases. They also stay up to date by:
Regularly reviewing medical research.12
Tracking the work of other health agencies around the world.12
Following guidance from the World Health Organization Global Advisory Committee on Vaccine Safety (WHO GACVS).12
Health Canada and PHAC will take appropriate action if they identify a new health risk tied to a vaccine. For example, Canada has clear laws and procedures in place to either recall a vaccine or stop the delivery of a specific batch if a serious safety concern is detected.14
-
The flu, Tdap, RSVpreF and mRNA COVID-19 vaccines are safe for pregnant people and their babies. Research shows that getting these vaccines during pregnancy does NOT increase the risk of complications (problems) during pregnancy or birth.
Influenza (Flu) Vaccine:
The flu vaccine is safe for pregnant people and for their babies. Studies15-19 show that for pregnant people vaccinated against the flu during pregnancy there was:
No increase in the risk of premature birth (birth before 37 weeks of pregnancy)
No increase in the risk of birth defects
No increase in the risk of miscarriage
No difference in average gestational age or birth weight
Lower rates of stillbirth among women who got the flu vaccine in pregnancy, compared to mothers who didn’t.
Tdap (tetanus, diphtheria, pertussis) Vaccine:
The Tdap vaccine is safe for pregnant people and for their babies. Specifically, a review of many studies20 confirmed that for pregnant people vaccinated against tetanus, diphtheria, and pertussis during pregnancy there was:
No increase in the risk of preterm birth (birth before 37 weeks of pregnancy)
No increase in the risk of stillbirth or neonatal death (death during the first 28 days of life)
No increase in the risk of babies that were small for gestational age
No increase in the risk of low birth weight (less than 2.5kg)
No increase in the risk of birth defects
mRNA COVID-19 Vaccines:
mRNA COVID-19 vaccines, including all recommended booster doses, are safe for pregnant people and their babies. Studies21-23 show that for pregnant people vaccinated against COVID-19 during pregnancy there was:
No increase in the risk of pregnancy loss (miscarriage)
No increase in the risk of preterm birth (birth before 37 weeks of pregnancy)
No increase in the risk of stillbirth
No increase in the risk of low birth weight
On the other hand, we do know that getting a COVID-19 infection during pregnancy does increase the risk of these serious problems. Studies have shown that catching a COVID-19 infection during pregnancy can increase the risk of:
Preterm birth (birth before 37 weeks of pregnancy)
Low birth weight
Babies being admitted to a neonatal intensive care unit (NICU) with COVID-related complications.24
Maternal RSVpreF Vaccine:
The RSVpreF vaccine approved for use during pregnancy helps protect both you and your baby by reducing the risk of severe RSV infections.
The approval process for the maternal RSVpreF vaccine was unique because it included pregnant individuals in the clinical trials. This provides strong evidence that the vaccine is safe and effective during pregnancy.
Here’s what the studies show:
In studies conducted in Argentina and South Africa, preterm births (babies born before 37 weeks) occurred in 5.6% of pregnant people vaccinated between 24-36 weeks of pregnancy, compared to 4.7% of those who did not get the vaccine.10-12
When the vaccine was given during the recommended period of 32-36 weeks, preterm births occurred in 4.2% of vaccinated pregnant people compared to 3.7% of those unvaccinated.10-12 These small differences were not statistically significant, meaning they could have happened by chance.
It's important to know that in Canada, up to 8% of babies are born prematurely, which is the typical rate for the general population. This means the rates of preterm birth seen in the study are actually lower than what we see in real life.4
In other regions like Canada, the US, and Europe, there was no difference in the rate of preterm births between those who received the RSVpreF vaccine and those who didn’t.4,13
There is also no evidence that the RSVpreF vaccine affects future fertility or increases the risk of miscarriage.4,13
While any medication can come with potential risks, real-life data consistently shows that the vaccines recommended during pregnancy are both safe and effective for protecting you and your baby. It's natural to have questions about your health and your baby’s health, and making decisions about vaccines is an important part of your prenatal care. If you have concerns or want to learn more, talk to your healthcare provider. They can offer personalized advice based on the latest research and your individual circumstances.
-
No. There is no risk that the flu, Tdap, RSVpreF or mRNA COVID-19 vaccines recommended in pregnancy will make you sick because they don’t contain a ‘live’ germ (virus or bacteria). This means that they can’t give you the disease or harm you or your baby in any way.
On the other hand, live or live-attenuated vaccines containing ‘live’ viruses or bacteria pose a theoretical risk to a developing baby and are not routinely recommended in pregnancy. The risk to developing babies is ‘theoretical’ because real-world data shows that babies born to a parent who got a live or live-attenuated vaccine during pregnancy (often without knowing they were pregnant at the time) don’t have higher rates of birth defects or infections related to the vaccine. This means that accidentally getting a live or live-attenuated vaccine during pregnancy is not a reason to consider terminating (ending) a pregnancy. Examples of live vaccines include measles, mumps, and rubella (MMR) and Varicella (chickenpox).
Talk to your healthcare provider about which vaccines are safe and recommended for you during pregnancy.
Video: Vaccine safety assessment in pregnancy
Video provided courtesy of the Immunising Pregnant Women and Infants Network (IMPRINT). Explore more IMPRINT videos and resources here.

Real-world evidence shows that getting vaccinated during pregnancy is a safe and effective way to protect you and your baby from infections.
Vaccine Reactions
-
Most people have no reaction to vaccination. Some have mild reactions that last between 12 and 24 hours and are easily treated at home. If your symptoms last longer than a couple of days, or if you are worried about how you feel after your vaccination, you can get help from your doctor or by calling the toll-free health information and advice phone service available in your province/territory:
British Columbia, Alberta, Saskatchewan, Ontario, Quebec, New Brunswick, Nova Scotia, Newfoundland and Labrador, New Brunswick, Prince Edward Island, the Yukon, the Northwest Territories: Call 811
Manitoba: Call 1-888-315-9257
Nunavut: Call 211
You can also get help by visiting your nearest emergency department or urgent care centre. If you develop any serious symptoms that you think could be an allergic reaction after your vaccination, call emergency services right away by dialling 911.
-
The reactions pregnant people have to vaccination are similar to those of adults who are not pregnant. Many people have no reaction at all, while others may experience some temporary side effects that usually last from a few hours to a few days after vaccination.
Common side effects after a vaccine include soreness, redness, and swelling where the vaccine was given, muscle or joint pain, fever, and/or chills.²⁵ These side effects are caused by your immune system's normal response to the vaccine and are usually quite mild, often going away on their own within a day or two.
Redness or soreness at the spot where the needle went in: The redness and soreness should start to feel better in a day or two. While you're waiting, you can use a cool, damp cloth on the area to help soothe it or take an over-the-counter pain medication like acetaminophen (Tylenol) if you need to.
Headache: The headache is likely to improve on its own, but if you feel the need for relief, you can consider taking an over-the-counter pain medication, such as acetaminophen (Tylenol).
Mild Fever: If you have a fever after your vaccination, drink plenty of water and consider using some acetaminophen (Tylenol) to help bring the temperature down.
Always make sure to check with your healthcare provider before taking any other pain medications.
-
Research shows that the flu, Tdap, and mRNA COVID-19 vaccines recommended in pregnancy do not increase the risk of pregnancy complications like miscarriage, premature birth, or stillbirth. Serious reactions to vaccination during pregnancy are also very rare. When they do happen, they are usually resolved with treatment from healthcare professionals or at a hospital, with both mother and baby returning to full health.
A very small number of people have a severe allergic reaction to vaccines called ‘anaphylaxis,’ which can cause swelling, hives, breathing difficulties, lowered blood pressure and, in severe cases, shock. Anaphylactic reactions are very rare – they occur in about one in a million people who have a vaccination.²⁶ In the very rare cases that an anaphylactic reaction happens after a vaccination, it happens shortly after the vaccine is received. That is why you will be asked to wait for a period of time after you get a vaccine so you can receive treatment in case of an allergic reaction.²⁷ Healthcare providers are trained to respond to an anaphylactic reaction.
If you develop any serious symptoms, call emergency services right away by dialling 911.
-
If your symptoms last longer than a couple of days, or if you are worried about how you feel after your vaccination, you can get help from your doctor or by calling the toll-free health information and advice phone service available in your province/territory:
British Columbia, Alberta, Saskatchewan, Ontario, Quebec, New Brunswick, Nova Scotia, Newfoundland and Labrador, New Brunswick, Prince Edward Island, the Yukon, the Northwest Territories: Call 811
Manitoba: Call 1-888-315-9257
For Nunavut: Call 211
You can also get help by visiting your nearest emergency department or urgent care centre. If you develop any serious symptoms that you think could be an allergic reaction after your vaccination, call emergency services right away by dialling 911.
-
The only medical reason for a pregnant person not to get vaccinated during pregnancy is if they have had a serious allergic (anaphylactic) reaction to one of these vaccines in the past.
Talk with your healthcare provider about any allergies you may have and whether you have had a reaction to the flu, Tdap, or COVID-19 vaccines before.
Vaccine Myths vs. Facts
-
There is currently no evidence to suggest that COVID-19 vaccines causes fertility problems in men or women. Current research28-31 shows:
No link between COVID-19 vaccines and infertility (problems getting pregnant).
No link between COVID-19 vaccines and increased risk of miscarriage or stillbirth.
No differences in the chances of conceiving a child between vaccinated and unvaccinated populations.
-
Results from recent studies31-32 show that some people who menstruate may experience some temporary changes in menstruation after getting a COVID-19 vaccine.33 These include:
Menstrual periods lasting for a longer time than usual
Less time between menstrual periods than usual
Bleeding during menstrual periods that is heavier than usual
These changes are usually small and fix themselves over time in 1 or 2 cycles.34 There are many ideas about why these changes happen, but the exact reasons are still unclear. According to the Society of Obstetricians and Gynaecologists of Canada (SOGC), many things can affect your period, like sleep, stress, sickness, what you eat, and how much you exercise.34 Regardless of these temporary changes in menstruation, there is no evidence that COVID-19 vaccination causes fertility problems.33
-
Some believe that catching a disease and recovering from it provides stronger immunity (protection against a disease) than vaccination. While it's sometimes true that this ‘natural immunity’ can last longer, the dangers of actually getting sick are much greater than any potential risks from vaccination.35
For example, pregnant people are more likely to get very sick from COVID-19. Having a serious case of COVID-19 in pregnancy increases the risk of complications (problems) like premature birth (birth that happens before 37 weeks of pregnancy) and stillbirth.35 On the other hand, serious reactions to the COVID-19 vaccine during pregnancy are very rare. Common side effects, like redness/soreness where you got the shot, a headache, or a slight fever, are usually mild and disappear in a few days. Even if you've already had COVID-19, getting vaccinated will give you an extra layer of protection against severe illness and hospitalization.35
-
ImmunizeBC. Vaccine ingredients [Internet]. [Vancouver, BC]: Public Health Association of BC; Date last reviewed: 2024 May 14 [cited 2024 Oct 4]. Available from: https://immunizebc.ca/vaccine-safety/ingredients
Children's Hospital of Philadelphia, Vaccine Education Center. Aluminum in vaccines: What you should know [Internet]. [Philadelphia, PA]: Children's Hospital of Philadelphia; ©2023 [cited 2024 Oct 4]. Available from: https://media.chop.edu/data/files/pdfs/vaccine-education-center-aluminum.pdf
St-Amant O, Lapum J, Dubey V, Beckermann K, Huang C-S, Weeks C, Leslie K, English K. Vaccine practice for health professionals: 1st Canadian edition [Internet]. eCampusOntario; 2020 [cited 2024 Oct 4]. Available from: https://openlibrary-repo.ecampusontario.ca/jspui/handle/123456789/650
Centers for Disease Control and Prevention. How mRNA COVID-19 vaccines work [Internet]. Infographic. [Atlanta, GA]: Centers for Disease Control and Prevention; [cited 2024 Oct 4]. Available from: https://archive.cdc.gov/www_cdc_gov/coronavirus/2019-ncov/downloads/vaccines/COVID-19-mRNA-infographic_G_508.pdf
Centers for Disease Control and Prevention. COVID-19 vaccine basics [Internet]. [Atlanta, GA]: CDC; 2024 Sep 3 [cited 2024 Oct 4]. Available from: https://www.cdc.gov/covid/vaccines/how-they-work.html#:~:text=Instead%2C%20mRNA%20vaccines%20use%20mRNA,that%20germ%20in%20the%20future.
ImmunizeBC. Vaccine testing, approval, and monitoring [Internet]. [Vancouver, BC]: Public Health Association of BC; 2024 Jun 25 [cited 2024 Oct 4]. Available from: https://immunizebc.ca/vaccine-safety/testing-approval-and-monitoring
Health Canada. Regulating vaccines for human use in Canada [Internet]. Ottawa (ON): Health Canada; 2020 Sep 9 [cited 2024 Oct 4]. Available from: https://www.canada.ca/en/health-canada/services/drugs-health-products/biologics-radiopharmaceuticals-genetic-therapies/activities/fact-sheets/regulation-vaccines-human-canada.html
Health Canada. Vaccine development and approval process (infographic) [Internet]. 2022 Apr 13 [cited 2024 Oct 4]. Available from: https://www.canada.ca/en/health-canada/services/drugs-health-products/covid19-industry/drugs-vaccines-treatments/vaccines/development-approval-infographic.html
Public Health Agency of Canada. Vaccines and treatments for COVID-19: progress [Internet]. Ottawa (ON): Public Health Agency of Canada; 2022 Jul 25 [cited 2024 Oct 4]. Available from: https://www.canada.ca/en/public-health/services/diseases/2019-novel-coronavirus-infection/prevention-risks/covid-19-vaccine-treatment.html
Health Canada. Notice: expedited review of health product submissions and applications to address COVID-19 [Internet]. Ottawa (ON): Health Canada; 2022 Feb 21 [cited 2024 Oct 4]. Available from: https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/announcements/notice-expediated-review-health-products-covid-19.html
Health Canada. Vaccine development and approval in Canada [Internet]. Ottawa (ON): Health Canada; 2022 Apr 13 [cited 2024 Oct 4]. Available from: https://www.canada.ca/en/health-canada/services/drugs-health-products/covid19-industry/drugs-vaccines-treatments/vaccines/development-approval-infographic.html
Public Health Ontario. Vaccine safety [Internet]. Toronto (ON): Public Health Ontario; updated 2024 Mar 1 [cited 2024 Oct 4]. Available from: https://www.publichealthontario.ca/en/health-topics/immunization/vaccine-safety
Public Health Agency of Canada. Reporting adverse events following immunization (AEFI) in Canada: user guide to completion and submission of the AEFI reports [Internet]. Ottawa (ON): Public Health Agency of Canada; 2023 Oct 30 [cited 2024 Oct 4]. Available from: https://www.canada.ca/en/public-health/services/immunization/reporting-adverse-events-following-immunization/user-guide-completion-submission-aefi-reports.html
MacDonald NE, Law BJ. Canada’s eight-component vaccine safety system: a primer for health care workers. Paediatrics & child health. 2017 Jul 1;22(4):e13-6. https://doi.org/10.1093/pch/pxx073
Fell DB, Platt RW, Lanes A, Wilson K, Kaufman JS, Basso O, Buckeridge D. Fetal death and preterm birth associated with maternal influenza vaccination: systematic review. BJOG: An International Journal of Obstetrics & Gynaecology. 2015 Jan;122(1):17-26. doi:10.1111/1471-0528.12977.
McMillan M, Porritt K, Kralik D, Costi L, Marshall H. Influenza vaccination during pregnancy: a systematic review of fetal death, spontaneous abortion, and congenital malformation safety outcomes. Vaccine. 2015 Apr 27;33(18):2108-17. doi:10.1016/j.vaccine.2015.02.068.
Regan AK, Moore HC, de Klerk N, Omer SB, Shellam G, Mak DB, et al. Seasonal trivalent influenza vaccination during pregnancy and the incidence of stillbirth: population-based retrospective cohort study. Clin Infect Dis. 2016;62(10):1221-7. doi:10.1093/cid/ciw082.
McHugh L, Andrews RM, Lambert SB, Viney KA, Wood N, Perrett KP, et al. Birth outcomes for Australian mother-infant pairs who received an influenza vaccine during pregnancy, 2012-2014: the FluMum study. Vaccine. 2017;35(10):1403-9. doi:10.1016/j.vaccine.2017.01.075.
Regan AK, Wesselink AK, Wang TR, Savitz DA, Yland JJ, Rothman KJ, Hatch EE, Wise LA. Risk of miscarriage in relation to seasonal influenza vaccination before or during pregnancy. Obstet Gynecol. 2023;142(3):625-35. doi:10.1097/AOG.0000000000005279.
McMillan M, Clarke M, Parrella A, Fell DB, Amirthalingam G, Marshall HS. Safety of tetanus, diphtheria, and pertussis vaccination during pregnancy: a systematic review. Obstet Gynecol. 2017;129(3):560-73. doi:10.1097/AOG.0000000000001888.
Juliá-Burchés C, Martínez-Varea A. An update on COVID-19 vaccination and pregnancy. J Pers Med. 2023;13(5):797. doi:10.3390/jpm13050797.
Prasad S, Kalafat E, Blakeway H, et al. Systematic review and meta-analysis of the effectiveness and perinatal outcomes of COVID-19 vaccination in pregnancy. Nat Commun. 2022;13:2414. doi:10.1038/s41467-022-30052-w.
Ma Y, Deng J, Liu Q, Du M, Liu M, Liu J. Effectiveness and safety of COVID-19 vaccine among pregnant women in real-world studies: a systematic review and meta-analysis. Vaccines. 2022;10(2):246. doi:10.3390/vaccines10020246.
ImmunizeBC. Immunization & pregnancy [Internet]. 2024 Jun 24 [cited 2024 Oct 4]. Available from: https://immunizebc.ca/adults/pregnancy#:~:text=If%20you%20are%20pregnant%20and,and%20hospitalization%20from%20COVID%2D19.
Society of Obstetricians and Gynaecologists of Canada. Vaccination [Internet]. [cited 2024 Oct 4]. Available from: https://www.pregnancyinfo.ca/your-pregnancy/routine-tests/vaccination/.
McNeil MM, Weintraub ES, Duffy J, Sukumaran L, Jacobsen SJ, Klein NP, et al. Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol. 2016;137(3):868-78. doi:10.1016/j.jaci.2015.07.048.
Health Canada. Reported side effects following COVID-19 vaccination in Canada [Internet]. 2023 Sep 29 [cited 2023 Oct 4]. Available from: https://health-infobase.canada.ca/covid-19/vaccine-safety/summary.html
Zaçe D, La Gatta E, Petrella L, Di Pietro ML. The impact of COVID-19 vaccines on fertility: a systematic review and meta-analysis. Vaccine. 2022;40(42):6023-34. https://doi.org/10.1016/j.vaccine.2022.09.019
Wesselink AK, Hatch EE, Rothman KJ, Wang TR, Willis MD, Yland J, Crowe HM, Geller RJ, Willis SK, Perkins RB, Regan AK. A prospective cohort study of COVID-19 vaccination, SARS-CoV-2 infection, and fertility. American journal of epidemiology. 2022 Aug;191(8):1383-95. https://doi.org/10.1093/aje/kwac011
Wong Y, Elwood C, Money D, Dunne C. Myths versus facts: COVID-19 vaccine effects on pregnancy, fertility, and menstruation. BC Med J. 2022;64(8):354-6.
Edelman A, Boniface ER, Benhar E, Han L, Matteson KA, Favaro C, Pearson JT, Darney BG. Association between menstrual cycle length and coronavirus disease 2019 (COVID-19) vaccination: a US cohort. Obstetrics & Gynecology. 2022 Apr 1;139(4):481-9. DOI: 10.1097/AOG.0000000000004695
Nazir M, Asghar S, Rathore MA, Shahzad A, Shahid A, Khan AA, Malik A, Fakhar T, Kausar H, Malik J. Menstrual abnormalities after COVID-19 vaccines: A systematic review. Vacunas. 2022 Sep 1;23:S77-87. https://doi.org/10.1016/j.vacun.2022.07.001
Centers for Disease Control and Prevention. COVID-19 vaccine frequently asked questions [Internet]. 2024 Aug 30 [cited 2024 Oct 4]. Available from: https://www.cdc.gov/covid/vaccines/faq.html?CDC_AAref_Val=https://www.cdc.gov/coronavirus/2019-ncov/vaccines/faq.html
Society of Obstetricians and Gynaecologists of Canada. COVID-19 vaccines: myths and facts [Internet]. 2021 [cited 2024 Oct 4]. Available from: https://sogc.org/common/Uploaded%20files/Covid%20Information/FAQ_Myth-Fact_17Sept2021.pdf
Johns Hopkins Medicine. COVID-19 vaccine: what you need to know [Internet]. 2024 Sep 27 [cited 2024 Oct 4]. Available from: https://www.hopkinsmedicine.org/health/conditions-and-diseases/coronavirus/covid-19-vaccine-what-you-need-to-know